Principal Associate Director/Director, Translational Biology

Location: South San Francisco, CA / Flexible

TRexBio is a discovery stage biotechnology company leveraging cutting edge computational biology tools, a focus on human tissue, and expertise in immunobiology to develop revolutionary therapeutics for inflammatory diseases. Our powerful ‘deep biology’ discovery engine maps human tissue Treg behavior to disease processes, allowing us to identify and characterize novel targets for therapeutic intervention. Leveraging this platform, we are building a broad portfolio of novel therapies that modulate the immune system to restore human tissue immune homeostasis.

Our Culture:

At TRexBio, you will have the opportunity to work with amazingly smart humans who strive to make the world a better place. In addition to our team-centric culture, we believe that your individual creativity will help us to be our best. Our staff happy hours, organized by our Culture Club, bring us all together in creative and social activities. Our colleagues admire and respect one another.  We celebrate our wins, update company news, and acknowledge each other’s achievement weekly and monthly at all company meetings that celebrate our work and our people.

Position Summary:

We are seeking a talented and highly-motivated scientist to join our Translational Biology Research group. Our team is dedicated to the exploration of target biology and drug mechanisms. This position will direct in vitro immunology activities, focusing on the use of primary cells to understand the role of our target molecules in immune biology and to elaborate on the means by which our drug candidates modulate the immune system. Prior drug development experience in immunomodulatory biologics is required. The candidate is expected to have deep knowledge of immune-related disease biology and up-to-date expertise in immunology research methodology and technology.

Key Responsibilities include but are not limited to:

  • Direction of a team of scientists to design and perform primary immune cell in vitro assays to support target validation and drug development
  • Possible leadership of cross-functional program teams

Required Qualifications:

  • PhD in immunology (or closely-related field)
  • 8+ years of postdoctoral industry experience, including at least 6 years in immunology-related protein therapeutics
  • Expertise in in vitro assay systems based on primary immune cell biology, including assays utilizing human cellsRelevant technologies include high-parameter flow cytometry, ELISA, Incucyte, and Luminex
  • Experience directing research activities during the IND-enabling phase of biologic drug development
  • Detail-oriented and analytical with excellent problem-solving skills
  • Proven ability to collaborate in a team-oriented, matrixed environment
  • Management experience
  • Good planning and organizational skills to meet deadlines

Preferred Qualifications:

  • Experience in assays designed to address the adaptive immune system is preferred, innate immunity-related assay experience is a plus

TRexBio offers a very competitive benefits including medical, dental, vision, short/long term disability, life insurance as well as 401(k) match, bonus and paid time leave.

TRexBio is proud to be an AA/EEO employer and all qualified candidates will receive consideration without regard to characteristics protected by applicable local, state, or federal law, such as race, color, sex, age, religion, national origin, physical or mental disability, pregnancy, marital status, veteran or military status, genetic information, or sexual orientation.

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