(Senior) Research Associate/Associate Scientist/Scientist, Molecular and Cellular Biology

Location: South San Francisco, CA / Flexible

TRexBio is a discovery stage biotechnology company leveraging cutting edge computational biology tools, a focus on human tissue, and expertise in immunobiology to develop revolutionary therapeutics for inflammatory diseases. Our powerful ‘deep biology’ discovery engine maps human tissue Treg behavior to disease processes, allowing us to identify and characterize novel targets for therapeutic intervention. Leveraging this platform, we are building a broad portfolio of novel therapies that modulate the immune system to restore human tissue immune homeostasis.

Our Culture:

At TRexBio, you will have the opportunity to work with amazingly smart humans who strive to make the world a better place. In addition to our team-centric culture, we believe that your individual creativity will help us to be our best. Our staff happy hours, organized by our Culture Club, bring us all together in creative and social activities. Our colleagues admire and respect one another.  We celebrate our wins, update company news and acknowledge each other’s achievement weekly and monthly at all company meetings that celebrate our work and our people.

Position Summary:

TRexBio is seeking talented and highly motivated scientists to join our Molecular and Cellular Biology group. This position offers an opportunity to work as part of a small, dynamic team to elucidate and model target biology through in vitro assays.  The successful candidate will develop robust, target specific cell-based binding and functional assays to screen and rank therapeutic antibodies or protein therapeutics for lead selection. The focus of the position is to conduct laboratory-based experiments.  Attention to detail is a must along with strong skills in multi-tasking, optimizing robust assays, troubleshooting technical issues during assay development and the ability to organize, summarize and present results to technical teams.

Key Responsibilities include but are not limited to:

  • Gain proficiency in modulating novel targets on Tregs and other immune cells with monoclonal antibodies
  • Actively participate as an integral team member to identify best therapeutic biologics
  • Enjoy the process of problem solving by developing functional in vitro cell-based assays and executing the assay to answer biological questions
    • Surface protein expression assays using multi-color flow cytometry
    • Cell-binding activity
    • Ligand-binding inhibition assays
    • Functional assays (proliferation, cytokine responses)
    • Signaling assays (protein phosphorylation, calcium flux, transcription)
  • Support and develop serological assays including ELISA and cytokine analyses using multiplex assays
  • Collaborate with other departments to support transfer of knowledge
  • Be rigorous and thoughtfully critical in design and execution of protocols, documentation, and technical reports
  • Considerate communicator who is adept in presenting own work to team members and collaborators

Required Qualifications:

  • BS in immunology, biology, or related discipline with 2 years industry experience for Associate Scientist level
  • BS with 7+ years of experience, MS with 5 years of experience or PhD with 0-2 years of experience for Scientist position
  • Experience with mammalian cell culture and either serum-based or cell-based immunological assays to assess the activity of proteins are essential: (any) ELISA, multiplex analysis (Luminex, MSD), cell-based functional assays (proliferation, activation, cytokine responses), lentiviral and CRISPR-based applications, reporter-based assay platforms
  • Hands-on experience in isolation, expansion, and differentiation of primary immune cells (human, mouse and NHP), multi-color flow cytometry (8+ colors using Fortessa and Attune flow cytometers), intracellular cytokine staining, or Incucyte experience is a plus
  • Exceptional candidates will be familiar with more advanced functional immune cell assays including adhesion, cytotoxicity, or other cell-cell or cell-matrix interaction assays
  • Experience with FACSDiva, FlowJo, Prism, and Microsoft Office programs
  • You are curious to learn new biology, insightful, detail-oriented, organized, collaborative, and flexible with a positive “can-do” attitude

TRexBio offers a very competitive benefits including medical, dental, vision, short/long term disability, life insurance as well as 401(k) match, bonus, and paid time leave.

TRexBio is proud to be an AA/EEO employer and all qualified candidates will receive consideration without regard to characteristics protected by applicable local, state, or federal law, such as race, color, sex, age, religion, national origin, physical or mental disability, pregnancy, marital status, veteran or military status, genetic information, or sexual orientation.

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