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Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases
Editorial: Role of tissue-localized regulatory T cells in health and disease
Smith et al., Front Immunol. 2025 Oct 28:16:1718891.
Treg specialization and functions beyond immune suppression
Astarita et al., Clin Exp Immunol. 2023 Mar 16;211(2):176-183.
Tissue regulatory T cells: regulatory chameleons.
Muñoz-Rojas et al., Nat Rev Immunol. 2021 Mar 26;21(9):597-611.
Clinical, Immunological, and Genetic Features in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) and IPEX-like Syndrome
Jamee et al., J Allergy Clin Immunol Pract. 2020 Sep;8(8):2747-2760.e7.
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair
Boothby et al., Sci Immunol. 2020 May 1;5(47):eaaz9631.
Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair
Mathur et al., Immunity. 2019 Mar 19;50(3):655-667.e4.
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation
Ali et al., Cell. 2017 Jun 1;169(6):1119-1129.e11.
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.
Rubtsov et al., Immunity. 2008 Apr;28(4):546-58.
Selective expansion of functional Tregs and induction of clinically relevant regulatory biomarkers in Healthy Volunteers by TRB-061, a novel TNFR2 agonist indevelopment for immune mediated diseases
TNFR2 signaling promotes monocytic-MDSC differentiation and production of immunosuppressive mediator
1) Tsuji et al., FEBS Lett. 2026 Apr;600(8):1211-1221.
TNFR2 signalling in inflammatory diseases
Williams et al., Best Pract Res Clin Rheumatol. 2024 May;38(2):101941.
Tregs from human blood differentiate into nonlymphoid tissue–resident effector cells upon TNFR2 costimulation
Mensink et al., JCI Insight. 8;9(5):e172942 March 2024
Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis
Sharifkhodaei et al., iScience. 2023 Sep 4;26(10):107829.
IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function
Skartsis et al., Front Immunol. 2021 Dec 23:12:783282.
Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases
Yang et al., Cell Death Dis. 2019 Jan 10;10(1):27.
PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma
Lim et al., Nat Immunol. 2025 Jul;26(7):1074-1086.
Dysregulated T-cell homeostasis and decreased CD30+ Treg proliferating in aplastic anemia
Sun et al., Heliyon. 2024 Aug 3;10(15):e35775.
CD30L/CD30 protects against psoriasiform skin inflammation by suppressing Th17-related cytokine production by Vγ4+ γδ T cells
Yue et al., J Autoimmun. 2019 Jul:101:70-85.
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice
Sun et al., Gastroenterology. 2008 Feb;134(2):447-58.
Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease
5) Zeiser et al., Blood. 2007 Mar 1;109(5):2225-33.